شماره ركورد كنفرانس :
5328
عنوان مقاله :
Thermodynamic evaluation of the effect of Cu2+ ion on the interaction of Ribavirin drug with BSA
پديدآورندگان :
Hadidi Saba s.hadidi@razi.ac.ir Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
كليدواژه :
Thermodynamic parameters , Ribavirin drug , BSA interaction , Copper ion , Hydrophobic interaction , Electrostatic force.
عنوان كنفرانس :
بيست و سومين كنفرانس شيمي فيزيك انجمن شيمي ايران
چكيده فارسي :
In this study, the effect of Cu2+ ion on the interaction between bovine serum albumin (BSA) and Ribavirin drug (Rib) was investigated by fluorescence spectroscopy. The negative sign of free energy (ΔG) confirmed that Rib-BSA reaction is spontaneous both in the absence and presence of Cu2+ ions. The positive values for ΔH and ΔS indicated that hydrophobic interactions play major roles in Rib-BSA association in the absence of Cu2+ ion, while in the presence of Cu2+ ion, it is the electrostatic interaction that play essential role in the binding process.
