شماره ركورد كنفرانس :
5339
عنوان مقاله :
investigation of physicochemical properties of budesonide-loaded nanoliposomes prepared by thin-film hydration method
پديدآورندگان :
badiei mahtab mahtab.bde@gmail.com Faculty of Engineering, University of Isfahan, Iran , saraf Mohsen m.saraf@eng.ui.ac.ir Dept. of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Iran , badiee zohreh badiei@med.mui.ac.ir Dept. of Medical Sciences, University of Medical Sciences, Isfahan, Iran
كليدواژه :
budesonide , inflammation , nano , system , liposome
عنوان كنفرانس :
دوازدهمين كنفرانس بين المللي مهندسي مواد و متالورژي
چكيده فارسي :
Budesonide is an inhaled corticosteroid with anti-inflammatory properties but, at the same time, it has systemic adverse effects. In this study, nanoliposomes containing Budesonide were synthesized then their physicochemical properties were evaluated. The aim of this investigation is to design the inhalation nano-system in order to minimize systemic side effects, obtain more effective and prolonged drug release in the lung area, and prevent the involvement of other organs of the body. According to the results of the Zeta sizer device nanoparticles have an average size of 115 nm and based on the results of atomic force microscopy nanoparticles have uniform dispersion with a spherical morphology also based on drug release studies this formulation is able to sustain the drug release for more than 24 hours.
