پديدآورندگان :
Nematpour Najmeh Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran , Moradipour Pouran Nano Drug Delivery research center, Kermanshah University of Medical Sciences, Kermanshah, Iran , Zangeneh Mohammad Mahdi School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran , Arkan Elham Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran , Abdoli Mohadese Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran , Behbood Leila Pharmaceutical sciences research center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. leila_behbood@yahoo.com
كليدواژه :
Dextran , Sodium alginate , Clotrimazole , Mucoadhesive , Vaginal drug delivery , Antifungal patch
چكيده فارسي :
Aim and Background: Candidiasis is the origin of several chronic diseases and causes a wide range of symptoms from mucosal to systemic and deadly infections. Vaginal patches are one of the best drug delivery systems for the treatment of fungal infections in the vaginal environment, so a mucoadhesive film containing drugs such as clotrimazole and metronidazole is commercially available for patients. In the present study, a physicochemical comparison is made between clotrimazole loaded film and nanofiber fabricated with the new hybrid mucoadhesive formulation of dextran and alginate. Methods: Toxicity testing was performed using the MTT assay. Bioadhesion and antifungal effects were investigated for fibers and films. The release behavior of clotrimazole from two systems was evaluated by Frantz cell in each case. Results and discussion: The most important difference between nanofibrous and film mats was obtained in antifungal, mucoadhesive, Yong s modulus and morphology. The nanofiber has a higher antifungal effect and two-fold adhesive to the mouse tissue, than film. The inherent flexibility of nanofiber obviated the need for a plasticizer, which may have cytotoxic side effects. Conclusion: A nanofibrous mat is preferable relative to the same formulation of the film with approximately the same release profiles
