پديدآورندگان :
Pourmansouri Zeinab Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. , Malekkhatabi Atefeh Department of Pharmaceutical Biomaterials, Tehran University of Medical Sciences, Tehran, Iran , Toolabi Maryam Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran , Akbari Mahsa Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran , Hosseini Seyed Hojjat Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , Shahbazi Mohammad Ali Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Department of Biomedical Engineering and W.J. Kolff Institute for Biomedical Engineering and Materials Science, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, AV Groningen, 9713 The Netherlands , Rostami Ali Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. rostami@zums.ac.ir,
كليدواژه :
Sufentanil , dissolving microneedle , mice , hot plate technique
چكيده فارسي :
Aim and Background: Transdermal administration of narcotics can provide analgesia without serious side effects if it can penetrate the stratum corneum. Microneedle is a means of delivering medicine with minimal invasiveness. We decided to fabricate dissolving sufentanil microneedles (SPDMNs) in the current study, because to date no microneedle preparation of it has been made in the pharmaceutical market. Methods: The fabrication process, mechanical properties, and animal studies were examined. Results and discussion: SPDMNs had acceptable properties and could easily pass the tests. Conclusion: Our SPDMNs could easily pass characterization tests and can be used as a good drug delivery method for pain management with no dependence.