شماره ركورد كنفرانس :
5498
عنوان مقاله :
Propofol Unveiled: A Novel Approach to Inducing Diabetes in Wistar Rats
عنوان به زبان ديگر :
Propofol Unveiled: A Novel Approach to Inducing Diabetes in Wistar Rats
پديدآورندگان :
Golian Hamidreza golian.hosein@gmail.com Department of Biotechnology, Faculty of Sciences and Advanced Technologies in Biology Majors, University of Science and Culture, Tehran, Iran , Mirdar-Soltani Mehrshad mehrshad.mirdarsoltani@stu.usc.ac.ir Department of Biotechnology, Faculty of Sciences and Advanced Technologies in Biology Majors, University of Science and Culture, Tehran, Iran , Hamami Tannaz tannaz.hamami@gmail.com Department of Toxicology, Faculty of Medical Sciences and Pharmacy, University of Tehran, Tehran, Iran , Heidari Sara Heidarisara01@gmail.com Department of Biotechnology, Faculty of Biological Sciences, University of Kharazmi, Karaj, Iran , Nasri Shilan shilannasri@yahoo.com Department of Life Science Engineering, Faculty of New Sciences and Advanced Technologies, University of Tehran, Tehran, Iran
كليدواژه :
Propofol , Alloxan , Streptozotocin , Diabetes , Pancreatic Beta Cells
عنوان كنفرانس :
اولين كنفرانس بين المللي و چهارمين كنفرانس ملي تجهيزات و فناوري هاي آزمايشگاهي
چكيده فارسي :
Alloxan and streptozotocin are commonly used to induce diabetes in animal models. They destroy pancreatic beta cells through different mechanisms. However, their limitations include laboratory toxicity and low efficacy at high doses. Combining a new generation of diabetes-inducing agents with propofol offers improved efficiency, effectiveness, and costeffectiveness. Both substances cause diabetes by generating reactive oxygen species, but the source of these radicals differs. Alloxan and its reduced product, dialuric acid, create superoxide radicals, leading to pancreatic tissue damage. Streptozotocin enters beta cells through GLUT2 and induces DNA alkylation, depleting NAD+ and ATP levels, and increasing xanthine oxidase enzyme activity. Propofol intensifies the defects caused by the other substances, triggering nerve pathways that inhibit repair and producing free radicals, which damage the pancreas. In the study, alloxan, streptozotocin, and propofol induced diabetes in 40 Wistar laboratory rats, resulting in hyperglycemia and reduced insulin secretion.
