شماره ركورد كنفرانس :
5498
عنوان مقاله :
Targeted Glutathione-Sensitive Nanoparticles for Doxorubicin Delivery to Breast Cancer Cells
عنوان به زبان ديگر :
Targeted Glutathione-Sensitive Nanoparticles for Doxorubicin Delivery to Breast Cancer Cells
پديدآورندگان :
Babaei Mahsa babaeimahsa28@gmail.com Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran , Kashanian Soheila kashanian_s@yahoo.com Faculty of Chemistry, Sensor and Biosensor Research Center (SBRC), Razi University, Kermanshah, Iran , Salemi Zahra Department of Biochemistry, Arak University of Medical Sciences, Arak, Iran
كليدواژه :
Breast cancer , Chitosan , Doxorubicin , Hyaluronic acid , Glutathione
عنوان كنفرانس :
اولين كنفرانس بين المللي و چهارمين كنفرانس ملي تجهيزات و فناوري هاي آزمايشگاهي
چكيده فارسي :
Chitosan (Cs), a biocompatible and biodegradable polymer, has been widely used as a potential nanocarrier in recent years. Although, the positive charge of the Cs has limited its utilization as an effective nanoparticle (NPs) for the positive charge drugs. So, loading the DOX, a positive charge anticancer drug, into chitosan-based NPs is challenging. Herein, we offer a Cs derivation polymer by covalent linkage to L-Cysteine (L-Cys) for reducing the enhancing the entrapment efficiency (EE%) of DOX. Accordingly, the targeted DOX-loaded NPs based on Cs-Cys copolymer with redox-responsive properties were synthesized. At first, the Cs-CysNPs-DOX were synthesized by ion-gelation method, then they were targeted by Hyalouronic acid (HA). Ultimately, they were characterized in terms of size, zeta potential, EE%, and morphology. Also, in vitro drug release was analyzed. Overall, the suggested NPs demonstrated a high potential for targeted therapy and effective applications in biomedical research.
