Author/Authors
Christopher T. Walsh and R. Michael Garavito، نويسنده , , David L. DeWitt، نويسنده ,
DocumentNumber
1601528
Title Of Article
The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins
شماره ركورد
11769
Latin Abstract
Despite the marked differences in their physiological roles, the structures and catalytic functions of the cyclooxygenase isozymes COX-1 and -2 are virtually identical. Nevertheless, a handful of amino acid substitutions give rise to subtle differences in ligand binding between the two isoforms. These ‘small’ alterations of isozyme structure are sufficient to allow the design of new, isoform-selective drugs.
From Page
278
NaturalLanguageKeyword
cyclooxygenase , membrane protein , aspirin , Prostaglandin biosynthesis
JournalTitle
Studia Iranica
To Page
287
To Page
287
Link To Document