Karaman, S Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Günüşen, İ Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Ceylan, A Ordu Kadın Doğum ve Çocuk Hastalıkları Hastanesi - Anesteziyoloji ve Reanimasyon Kliniği, Turkey , Eyigör, C Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Sargın, A Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey

The effect of dexketoprofen trometamol on postoperative analgesia and morphine consumption in major gynecologic surgery

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Aim: The use of opioids and non-steroidal anti-inflammatory drugs in combination for postoperative pain is common. In this randomized, double-blind, placebo-controlled study, we aimed to evaluate the analgesic efficacy, the effects on opioid consumption and postoperative side effect of intravenous dexketoprofen trometamol, in comparison with a placebo, in patients undergoing major gynecologic surgery.Materials and Methods: This study was performed on 56 patients (ASAI-II) planned for major gynecologic surgery. The patients who were randomly allocated into two equal groups received intravenous dexketoprofen trometamol 50 mg (Group I) or serum physiologic (Group II) 15-20 min before the end of surgery and at every 8 h for 24 h postoperatively. All patients received standard general anesthesia. Hemodynamic parameters, pain and sedation score, morphine consumption, side effects and patient satisfaction were recorded postoperatively.Results: Although the pain scores and total morphine consumption (Group I: 34.8±11.7 mg, Group II: 60.0±18.5 mg) in the dexketoprofen group was lower, the side effects were similar between the groups. The amount of morphine use at 2, 4, 6, 12 and 24 h was significantly lower in Group I, sedation scores at 2 and 12 h were higher in Group II.Conclusion: Dexketoprofen trometamol is associated with a decrease in morphine consumption and superior analgesic efficacy in major gynecologic surgery.

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Postoperative analgesia , dexketoprofen trometamol , morphine , patient , controlled analgesia

Ege Journal Of Medicine

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