Özsan, N Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Sarsık, B Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Doğanavşargil, B Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Zekioğlu, O Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Özdemir, N Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey

Histopathological and immunohistochemical evaluation of sentinel lymph node biopsies in breast cancer

14791

Aim: Breast cancer is the most common malignity and cancer-related cause of death for women. Sentinel lymph node biopsy (SLNB) is a minimally invasive method for the evaluation of lymph node involvement. We aimed to determine the success of SLNB in predicting axillary lymph node (ALN) metastasis, the efficacy of intraoperative diagnosis of SLNB, and investigate a correlation with the characteristics of the primary tumour.Materials and Methods: Eighty-six patients with breast cancer who had undergone SLNB were included. Cases were re-evaluated with intraoperative histopathological diagnosis, axillary lymph node dissection (ALND), and primary tumour excision materials. The correlation between immunohistochemical characteristics (ER, PR, Her2, p53, and Ki67) of the primary tumour, and status of axillary metastasis were also investigated retrospectively.Results: Nine of 16 patients who had received ALND following the diagnosis of macrometastasis in SLNB intraoperatively, had ALN metastasis. Sixteen cases were diagnosed as micrometastasis or submicrometastasis in SLNB, and among them, only one out of 9 patients with completion of ALND, had metastasis in ALN. All 15 metastatic cases diagnosed intraoperatively had macrometastasis in paraffin sections. Cases within the good prognostic tumour group had low rates of metastasis in SLNB. Among the immunohistochemical markers performed for primary tumours, only Ki67 was found to be higher in cases with metastasis in SLNB.Conclusion: Our findings are in agreement with previous studies. If SLNB is negative for metastasis, SLNB is the reliable, appropriate and adequate way of axillary management with reduced arm-morbidity. Larger studies with long follow-up periods are needed to find out if completion of ALND is necessary for all patients with metastasis in SLNB.

80

Sentinel , breast cancer , micrometastases , axilla , isolated tumour cells

Ege Journal Of Medicine

87