The relationship between vitamin D level and lipid profile in patients admitted to Physical Medicine and Rehabilitation outpatient clinic

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Aim: Cardiovascular disease (CVD) is one of the leading causes of deaths worldwide. Epidemiological studies have shown an inverse association between serum 25-hydroxy vitamin D (25-OH D) and cardiovascular risk factors including lipid profile. However, it is still unclear whether 25-OH D level is causally related to the disease or is just a marker of lifestyle. Placebo-controlled trials that examined the effect of vitamin D supplementation on serum lipid profile have provided divergent results. The aim of this study is to investigate the relationship between serum vitamin D concentration and lipid profile. Materials and Methods: Two hundred and four patients admitted to physical medicine and rehabilitation outpatient clinic with the complaint of pain were included in this study. The demographic characteristics of patients were recorded. Fasting serum concentrations of 25-OH vitamin D, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride were measured.Results: The mean level of 25-OH D was 10.6±6.5 ng/mL, the prevalence of vitamin D deficiency was 92.2%. Patients were classified into 3 groups according to the 25-OH vitamin D levels as 20 ng/mL, 20-30 ng/mL, and 30 ng/mL. Although in patients with higher vitamin D concentration, serum levels of total cholesterol, TG, and LDL were lower and HDL was higher compared to patients with vitamin D deficiency, this association was not statistically significant (p 0.05). Conclusion: Given the prevalence of vitamin D insufficiency and the detrimental consequences of an unfavorable lipid profile, we believe that investigation, correction, and maintenance of vitamin D status may be indicated in high-risk populations.

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Vitamin D , cardiovascular disease , lipid profile

Ege Journal Of Medicine

176

Ege Journal Of Medicine