Author/Authors :
Erdogan, Oguz Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kulak Burun Bogaz AD, Turkey , Tüz, Mustafa Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kulak Burun Bogaz AD, Turkey , Yasan, Hasan Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kulak Burun Bogaz AD, Turkey , Aynali, Giray Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kulak Burun Bogaz AD, Turkey , Yariktas, Murat Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kulak Burun Bogaz AD, Turkey
Title Of Article :
The effect of caffeic acid phenethyl ester on experimental hearing loss caused by acoustic trauma
شماره ركورد :
15550
Abstract :
Objective: In this study, the effect of antioxidant caffeic acid phenethyl ester (CAPE) on hearing loss caused by acoustic trauma was investigated. Materials and Methods: Twenty rats were included in this study. Otoacoustic emissions were measured at the begining of study. Then, all the rats were exposed to sound at 4 kHz frequency and 120 dB intensity. The model of acoustic trauma was proved by measuring otoacoustic emissions following 24 hours of trauma. Twenty rats with acoustic trauma were divided into 2 groups; as 10 rats in control group and 10 rats in CAPE group. The solution of CAPE was prepaired with 10 percent ethanol, than, 10 µmol/kg dosage was injected intraperitoneally (as 2 ml/kg ). Control group animals were injected 2 ml/kg ethanol-salin (10%) which was used in the preparation of CAPE solution. Caffeic acid phenethyl ester was administered 24 h after acoustic trauma. The consecutive otoacoustic measurements of all rats were carried out of 1st, 3rd, 5th and 7th days of cafeic acid phenethyl ester administration. The formation of acoustic trauma model was also proved statistically. Results: There was no statistically significant difference between study and control groups according to the otoacoustic emission measurements at 1st, 3rd, 5th and 7th days after from cafeic acid phenethyl ester administration. Conclusion: Management with cafeic acid phenethyl ester 24 h after the acoustic trauma seem to have no an effect on the management of hearing loss caused by acoustic trauma. Cafeic acid phenethyl ester administration at 24th hour of acoustic trauma is delayed aplication. Cafeic acid phenethyl ester has no effect on the treatment of evolved acoustic trauma. However, further study is neccessary to investigate prophylactic effect of cafeic acid.
From Page :
81
NaturalLanguageKeyword :
Acoustic Trauma , Caffeic acid phenethyl ester , Antioxidant
JournalTitle :
Medical Journal Of Suleyman Demirel University
To Page :
86
Link To Document :
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