Author/Authors :
KARA, Murat Fırat Üniversitesi - Tıp Fakültesi - Tıbbi Genetik Anabilim Dalı, Türkiye , KARA, Bilge Harput Devlet Hastanesi - Psikiyatri Kliniği, Türkiye , EROL, Deniz Fırat Üniversitesi - Elazığ Sağlık Yüksek Okulu, Türkiye , YÜCE, Hüseyin Fırat Üniversitesi - Tıp Fakültesi - Tıbbi Genetik Anabilim Dalı, Türkiye , ATMACA, Murad Fırat Üniversitesi - Tıp Fakültesi - Psikiyatri Anabilim Dalı, Türkiye , TEKEDERELİ, İbrahim İnönü Üniversitesi - Tıbbi Biyoloji ve Genetik Anabilim Dalı, Türkiye
Abstract :
Objective: Major depression is a relatively common psychiatric disorder. The etiology remains to be elucidated. In this study, we investigated the relationship between major depression and the insertiondeletion polymorphism of angiotensin converting enzyme gene. Materials and Methods: The DNAs from patients (n=133) and healthy volunteers (n=119) were analysed by polymerase chain reaction (PCR). Results: The genotype (p 0,05) and allele (p=0,011) frequencies were statistically significant. Conclusion: We suggest that the insertiondeletion polymorphism of angiotensin converting enzyme is associated with major depression.
