ÖZGÜLER, Müge Elazığ Eğitim Araştırma Hastanesi - Enfeksiyon Hastalıkları Kliniği, Turkey , AKBULUT, Handan Fırat Üniversitesi - Tıp Fakültesi - İmmünoloji Anabilim Dalı, Turkey , AKBULUT, Ayhan Fırat Üniversitesi - Tıp Fakültesi - Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Turkey

Review of Interleukin-6 and Interleukin-18 Levels in Patients Diagnosed with Chronic Hepatitis B

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Objective: The hepatitis B virus (HBV) is a DNA virus of the Hepadnaviridae family. The course of infection depends on the patient’s immune response. Interleukin 6 (IL-6) and Interleukin-18 are significant cytokines for immune response. Chronic hepatitis B patients may exhibit insufficient immune response against the hepatitis B virus. There may be differences in interleukin 6 and interleukin 18 (IL-8) levels between patients and healthy controls. In this study, we aimed to assess the relationship between the level of IL-6 and IL-18, and chronicity of the disease in patients diagnosed with chronic Hepatitis B virus infection. Materials and Methods: Sixty-three treatments-naive patients diagnosed with chronic active hepatitis B infection who applied to our clinic between June 2010 and May 2011 were enrolled in the study. 5 mL of blood was collected from each patient and IL-6 and IL-18 levels were examined by the ELISA method. Results: The IL-6 and IL-18 levels of the control group were compared with those of the subjects in the patient group. The Mann-Whitney U test was used to evaluate the control group and the patient group, and it was found that the IL- 6 level was statistically higher in the patient group (p 0.011). There was no significance for IL-18 levels between the control group and the patient group with low viral load. However, we detected a statistically significant elevation in IL-18 levels of patient groups with high viral load compared to the control group. Conclusion: The response to IL-6 and IL-18 can be lower in patients, and the receptor resistance against IL-6 and IL-18 may have developed. This may be the reason for chronicity

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Chronic hepatitis B , proinflammatory cytokine , interleukin 6 , interleukin 18

Fırat University Medical Journal Of Health Sciences

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