HANEDAN USLU, Gonca Kanuni Eğitim ve Araştırma Hastanesi, Turkey , CANYILMAZ, Emine Karadeniz Teknik Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi Anabilim Dalı, Turkey , ZENGİN, Ahmet Kanuni Eğitim ve Araştırma Hastanesi, Turkey , SERDAR, Lasif Karadeniz Teknik Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi Anabilim Dalı, Turkey , YÖNEY, Adnan Karadeniz Teknik Üniversitesi - Tıp Fakültesi - Radyasyon Onkolojisi Anabilim Dalı, Turkey , GÖÇMEZ, Hüseyin Kanuni Eğitim ve Araştırma Hastanesi, Turkey

Two-Dimensional Conventional Radiotherapy Versus Intensity Modulated Radiotherapy for Nasopharyngeal Cancer Treatment: A Retrospective Study from Northeast Turkey

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Objective: This study aims to compare intensity-modulated radiotherapy (IMRT) and two- dimensional conventional radiotherapy (2DCRT) considering treatment response, treatment compliance, and toxicity in nasopharyngeal cancer (NPC) patients. Materials and Methods: A total of 78 NPC patients admitted between January 1999– December 2013 were retrospectively evaluated for local control (LC), treatment compliance, and toxicity. Of these, 55 (70.5%) were treated with 2DCRT, and 23 (29.5%) were treated with IMRT. Results: The median follow-up time was 34.1 months (range, 3.2–202.84). Xerostomia was the most common acute toxicity in both the 2DCRT (41, 77.4%) and IMRT (18, 78.3%) groups. The most common late toxicity occurred in 28 (51.9%) patients in the former was xerostomia, while that in the latter was soft tissue fibrosis in 13 (56.6%) patients. No differences between these treatments were observed considering acute or late toxicity. In the former, 23 patients (41.8%) interrupted the treatment, while in the latter only 4 patients (17.4%) interrupted it. This difference was statistically significant. Considering treatment response, no significant difference was noted. Conclusion: IMRT was better than 2DCRT for treatment of NPC considering treatment compliance, toxicity, and tumor response; however, prospective studies with more patients are needed for confirmation

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IMRT , nasopharyngeal cancer , radiotherapy , treatment techniques

Fırat University Medical Journal Of Health Sciences

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