Author/Authors :
Alpan, Ayşe Selcen Ege Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey , Yılmaz, Övgü Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Kılıçkaya, Ozan Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Kara, Pınar Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Güneş, Hasan Semih Ege Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey , Özsöz, Mehmet Şengün Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey
Title Of Article :
Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
Abstract :
In this study, synthesis and determination of interaction between DNA and 1Hbenzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA – drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively.
NaturalLanguageKeyword :
1H , benzimidazole , electrochemical genosensor , DNA , drug interaction , synthesis
JournalTitle :
Journal of Research in Pharmacy
