Bahçe, Muhterem Gülhane Askeri Tıp Fakültesi (GATF) - Genetik Bilim Dalı, Turkey , Beyan, Cengiz Gülhane Askeri Tıp Fakültesi (GATF) - Hematoloji Bilim Dalı, Turkey , Erdem, Gökhan Gülhane Askeri Tıp Fakültesi (GATF) - İç Hastalıkları Bilim Dalı, Turkey , Ateş, Ömer Gülhane Askeri Tıp Fakültesi (GATF) - Tıbbi Biyoloji Anabilim Dalı, Turkey , Kozan, Salih Gülhane Askeri Tıp Fakültesi (GATF) - Genetik Bilim Dalı, Turkey , Torun, Deniz Gülhane Askeri Tıp Fakültesi (GATF) - Genetik Bilim Dalı, Turkey , Güran, Şefik Gülhane Askeri Tıp Fakültesi (GATF) - Tıbbi Biyoloji Anabilim Dalı, Turkey

I(17q) in a case with myelodysplastic syndrome: an important and rarely seen chromosomal anomaly

19929

Myelodysplastic syndrome is a group of stem cell disorder that is characterized by ineffective hematopoiesis and transformation to acute leukemia. Genetic analyses have an important role in establishing the diagnosis and determining the appropriate chemotherapy. Here a patient with myelodysplastic syndrome in whom isochromosome of long arm of chromosome 17 [i (17q)] cytogenetic abnormality was detected is presented and clinical findings in patients with this anomaly are discussed. Although i(17q) cytogenetic abnormality is a very rarely seen genetic change in patients with myelodysplastic syndrome, it is accepted as a poor prognostic criterion according to literature findings. Thus patients of myelodysplastic syndrom with this cytogenetic abnormality may be considered as a different clinical syndrome during the follow-up and treatment.

301

Hematologic neoplasms , i(17q) , isochromosome , myelodysplastic syndrome , cytogenetic anomaly

Gulhane Medical Journal

303