Author/Authors
YÖNAL, İpek İstanbul Üniversitesi - İstanbul Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Turkey , SARGIN, Fatma Deniz İstanbul Üniversitesi - İstanbul Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Hematoloji Bilim Dalı, Turkey
Title Of Article
POLYCYTHEMIA VERA: UPDATE ON PATHOGENESIS, DIAGNOSIS AND MANAGEMENT
شماره ركورد
25985
Abstract
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass and usually overproduction of granulocytes and platelets and increased spleen size. JAK2V617F mutation is present in more than 95% of PV patients. Bone marrow examination reveals excessive proliferation of erythroid, myeloid, and megakaryocytic elements. The prognosis of PV depends on the severity of the complications occurring during the clinical course. Thrombotic complications are the main cause of morbidity and mortality in PV. Survival is affected whether appropriate therapy is applied during the erythrocytotic phase of the disease. Uncontrolled erythrocytosis poses very high risk for development of thrombosis. Some studies suggest that PV patients have a normal or near-normal life-expectancy. Most studies, however, report excess mortality caused by thrombotic complications and acute leukemia transformation during course of PV. This review aims to highlight the pathogenesis, diagnosis and current management in PV
From Page
83
NaturalLanguageKeyword
Acute leukemia transformation , Myeloproliferative neoplasm , Polycythemia vera , Thrombotic complications
JournalTitle
Journal Of Istanbul Faculty Of Medicine
To Page
91
JournalTitle
Journal Of Istanbul Faculty Of Medicine
Link To Document