Author/Authors :
Bagci, Gökhan İstanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey , Çinçin, Zeynep Birsu Istanbul Üniversitesi - Deneysel Tıp Arastırma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey , Dasdemir, Selçuk Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey , Özdemircan, Abdullah Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey , Karaali, Zeynep Ermis Haseki Egitim Arastirma Hastanesi - İç Hastalıkları Kliniği, Turkey , Çakmakoglu, Bedia İstanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey
Abstract :
The aim of our study was to investigate the effect of the MCP-1 A -2518G and CCR2 G190A polymorphisms on the development of diabetic coronary heart disease. Eighty one diabetic patient with coronary heart disease, 62 diabetic patient without coronary heart disease and 62 disease free controls were genotyped. There were significant differences between diabetic patient with coronary heart disease and control groups in MCP-1 A-2518G genotype (p:0,01 %2:9,11) and allele distribution (p:0,01 %2:6,53). MCP-1 AA genotype was significantly increased in coronary artery patients compared with controls but MCP-1 G allel frequency was increased in controls. On the other hand, there is no significant difference for CCR2 G190A polymorphism between patients and controls. In conclusion, we found that MCP-1 2518 AA genotype may cause diabetic coronary artery disease susceptibilty while G allel seems to be protective.
