Author/Authors :
özyavuz, mustafa kerem istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , çelik, faruk istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, turkey , işıkören, ece gizem istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, turkey , çelikel, burcu istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, turkey , çetiner, nur gökçe istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , çakmakoğlu, bedia istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , gökçe, muhammet oğuz istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey , zeybek, ş.ümit istanbul üniversitesi - aziz sancar deneysel tıp araştırma enstitüsü - moleküler tıp anabilim dalı, Turkey
Abstract :
Objective. According to the studies made with shizophrenia patients which emerge social rule violation behavior, strange facial expression, purposeless movements, staying away from other people and living alone also can show exrtemely addictive behavior to the relatives, inheritance ration of the children that have shizophreniz parents is 10-12 %. The aim of the thesis is to determine the effects of COX 2 gene polymorphism and serum levels on shizophrenia dissease Material and Methods. COX2 765 G C gene polymorphism was determined by using the appropriate protocol for PCRRFLP techniques. Serum levels were determined by using ELISA method. Results. In terms of COX2 765 G→C genotype and allele distribution between patients and control group there is significant difference in our study. GG genotype carying individuals in control group differs from others and this type of genotype gave them protection. CC genotype carying individuals in patients group are in high risk for dissease aproximately 5 fold. The frequencies of COX2 765 G→C G+genotype carying individuals in controls (95,5%) than in patients (82,1%) is important and gave protection to individuals from this dissease, also C+ genotype carying individuals frequencies in patients (58,9%) than controls (39,2%) significantly increase and have 2 fold risk fort he dissease. Conclusion. According to the results obtained from our research the connection between COX-2-765G→C polymorphism and G+ / GG genotype frequencies are protective, also it could be reported that CC and C+ genotype frequencies are lead to dissease. However, case number should be increased for for strengthening the thesis.
