Author/Authors :
Biçer, Asuman Etlik İhtisas Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Basar, Nurcan Türkiye Yüksek İhtisas Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Karasu, Betül Banu Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Karakurt, Özlem Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Kılıç, Harun Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Doğan, Mehmet Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Sarı, Münevver Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey , Akıs, Havva Kaya Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Dermatoloji Kliniği, Turkey , Eskioğlu, Fatma Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Dermatoloji Kliniği, Turkey , Akdemir, Ramazan Dıskapı Yıldırım Beyazıt Eğitim ve Arastırma Hastanesi - Kardiyoloji Kliniği, Turkey
Abstract :
Objectives: Psoriasis is a chronic infl ammatory skin disorder characterized by erythematous plaques, generally at the elbows, knees, scalp, umbilicus and lumber area. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the present study, we aimed to investigate QT dispersion (QTD) and corrected QT dispersion (QTcD) as a possible indicator of increased risk for ventricular arrhythmias and sudden cardiac death in patients with psoriasis. Materials and methods: Twenty-three patients with psoriasis and age and gender matched 20 control subjects were enrolled in the study. The severity of the disease was evaluated by the “Psoriasis Area and Severity Index (PASI)”. Standard 12-lead electrocardiographs at 25 mm/s paper speed and 24-hour holter examination were performed in all subjects. QTD and QTcD were measured. QTD was defi ned as the difference between the maximum and minimum QT interval measurements and QTc was calculated according to Bazett’s formula. Correlation analysis was performed between QTD and QTcD and PASI and duration of the disease. Results: QTD and QTcD were signifi cantly greater in psoriatic patients than controls (QTD, 67.5±17.4 vs 44.0±11.9 ms, p 0.001, respectively; QTcD, 72.4±17.6 vs 47.8±12.8 ms, p 0.001, respectively). There were a positive correlation between QTD and QTcD and PASI and longevity of psoriasis disease. Conclusion: In the present study, the patients with psoriasis have an increased QTD and QTcD when compared with healthy subjects and this increase was found to be correlated with the duration and severity of the disease.