Saçıkara, Muhammed Keçiören Eğitim ve Araştırma Hastanesi - İç Hastalıkları Klinikleri, Turkey , Nazlıgül, Yaşar Keçiören Eğitim ve Araştırma Hastanesi - Gastroenteroloji Klinikleri, Turkey , Kızılca, Güler Keçiören Eğitim ve Araştırma Hastanesi - İç Hastalıkları Klinikleri, Turkey , Bulur, Oktay Keçiören Eğitim ve Araştırma Hastanesi - İç Hastalıkları Klinikleri, Turkey

Doxycycline-induced esophagitis: Report of two cases and review of the literature

26379

Although it is not so frequent in medical literature, druginduced esophageal injury is important, because of its possible complications. Here, we reported two patients with ulcerative esophagitis secondary to doxycycline use. Both patients applied to outpatient clinic with retrosternal pain, odynofagia and dysphagia. Symptoms had been developed after three days of doxicycline treatment in the first patient, and after two days in the second patient. Upper gastrointestinal endoscopy revealed ulcers in patient 1 at the upper 1/3 segment of esophagus and in patient 2 at the middle 1/3 segment of esophagus. Based on the endoscopic findings, the patients were diagnosed as drug-induced esophageal injury resulting from doxycycline treatments. Doxycycline treatments were stopped and lansoprazole and sucralfate was started.Their symptoms improved in a few days following cessation of the drug. The esophagus was found as completely normal in control endoscopy performed after two weeks. Doxycycline can cause chemical esophagitis. Drug-induced esophagitis is a preventable cause of morbidity.

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Doxycycline , drug , induced esophagitis , esophageal injury.

Dicle Medical Journal

299