مرکز منطقه ای اطلاع رساني علوم و فناوري - Sitagliptin: New Oral Antidiabetic Agent for Tip 2 Diabetes Mellitus

Abstract :

Type 2 diabetes (T2DM), has become a world wide epidemic disorder and it has significant consequences for patients and also society. There are a lot of therapy protocols but because of having side effects (weight gain, hypoglycemia and gastrointestinal effects) and contraindications of existing treatments, new therapy protocols are necessary. So, a new approach called dipeptidyl peptidase-4 (DPP 4) inhibitors has been emerged called as sitagliptin. DPP 4 inhibition with sitagliptin reduces glucagon secretion and increases insülin secretion by preventing inactivation of glucagon-like peptide-1 (GLP-1), resulting in a balancing of blood glucose levels. Sitagliptin is safe and tolarable because of having a low risk of hypoglycemia. Many recent studies show that sitagliptin limits patients’ weight gain. Also in vitro studies sitagliptin increses beta cell mass and preserves pancreatic beta cell function. Sitagliptin can be used as monotherapy or combination therapy with other oral antidiabetic agents in tip 2 diabetes. In this study, the efficacy of sitagliptin on glycaemic control and effect of diabetic complications at T2DM patients, by reviewing the current studies.