Sarıkaya, Muhsin Afyon Kocatepe Üniversitesi - Afyon Kocatepe Üniversitesi - Kimya Bölümü, Turkey , Enginar, Hüseyin Afyon Kocatepe Üniversitesi - Fen Edebiyat Fakültesi - Kimya Bölümü, Turkey

Radioabeling Of L-Tyrosine With 131I and Investigation of Radiopharmaceutical Potantial

27549

131I labeled amino group containing aromatic substances are widely used in the diagnosis of diseases. In this study, radiolabeling of L-tyrosine with 131I, radiolabeling efficiency, in vitro stability, and biodistribution of radiolabelling substance were compared. Quality control stududies of radiolabeled substance (131I-L-trs) were carried out using Electrophoresis and Radio Thin Layer Chromatography (RTLC) methods. Biodistribution studies were done in nine male Albino Wistar rats which were categorized 3 groups. The rats were sacrificed at various time intervals (15, 60 and 180 min), their organs were removed, and percentage of injected dose per gram (% ID/g) was calculated. The radiolabelling yield of L- tyrosine was determined as % 92.32±2.74. Maximum uptake of 131I- L- tyrosine was seen in the stomach, kidneys, pancreas, thyroid and prostate. We concluded that the binding efficiency of 131I-L-tyrosine was high, an uptake concentration of 131I-L-tyrosine in the stomach was very high and 131I-L- tyrosine had sufficient stability for diagnostic studies.

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L , tyrosine , Biodistribution , I , 131 , İyodojen method

Afyon Kocatepe University Journal Of Science an‎d Engineering

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