Author/Authors :
sikine, m. université sidi mohamed ben abdallah - faculté des sciences et techniques - laboratoire de chimie organique appliquée, Maroc , kandri rodi, y. université sidi mohamed ben abdallah - faculté des sciences et techniques - laboratoire de chimie organique appliquée, Maroc , misbahi, h. université sidi mohamed ben abdellah - faculté des sciences et techniques - laboratoire de chimie organique appliquée, Morocco , chraibi, m. université sidi mohammed ben abdallah - faculté des sciences et techniques - laboratoire de biotechnologie microbienne, Morocco , kandri rodi, a. université sidi mohamed ben abdallah - faculté des sciences et techniques - laboratoire de chimie organique appliquée, Maroc , ouazzani chahdi, f. université sidi mohamed ben abdallah - faculté des sciences et techniques - laboratoire de chimie organique appliquée, Maroc , fikri benbrahim, k. université sidi mohammed ben abdallah - faculté des sciences et techniques - laboratoire de biotechnologie microbienne, Morocco , essassi, e.m. université mohamed v - faculté des sciences - laboratoire de chimie organique hétérocyclique, urac21, Maroc
Abstract :
New series of pyrido[2,3-b]pyrazine derivatives with various side-chains were investigated for their antibacterial activity. The synthesis were achieved from 5-bromo-2,3- diaminopyridine and oxalic acid according to a three-step procedure. All the products were tested in vitro on different bacteria strains and showed an average activity. The derivative bearing two thiocarbonyl groups exhibited good antibacterial activities against different strains Staphylococcus aureus (0.078mg/ml), Bacillus cereus (0.078mg/ml), and Escherichia coli (0.625mg/ml) ,S.typhi (1.25 mg/ml). The presence of side-chains on heterocyclic moiety decreased biological acivity.
NaturalLanguageKeyword :
pyrido[2,3 , b]pyrazine , PTC , antibacterial activity, minimum inhibitoryconcentration (MIC)
