Author/Authors
el janati, a. sidi mohamed ben abdellah university - faculty of science and technology - laboratory of applied organic chemistry, Fez, Morocco , kandri rodi, y. sidi mohamed ben abdellah university - faculty of science and technology - laboratory of applied organic chemistry, Fez, Morocco , misbahi, k. sidi mohamed ben abdellah university - faculty of science and technology - laboratory of applied organic chemistry, Fez, Morocco , ouazzani chahdi, f. sidi mohamed ben abdellah university - faculty of science and technology - laboratory of applied organic chemistry, Fez, Morocco , zouitini, a. sidi mohamed ben abdellah university - faculty of science and technology - laboratory of applied organic chemistry, Fez, Morocco , akhazzane, m. université sidi mohammed ben abdallah, Fès, Morocco , essassi, e. m. university mohammed v - faculty of sciences - laboratory of heterocyclic organic chemistry, Rabat, morocco
Title Of Article
SYNTHESIS OF NEW HETEROCYCLIC SYSTEMS CONTAINING QUINOXALINE MOIETY
شماره ركورد
28036
Abstract
The synthesis of a new brick heterocyclic system of quinoxaline was developed by a cyclocondensationreaction starting from o-phenylenediamine derivatives. Thus6 chloroquinoxaline-2,3(1H,4H)–dione was obtainedin excellent yield by condensation of4-Chloro-o-phenylenediamine with oxalic acid at reflux in a hydrochloric acid solution.Thealkylationreactions werethen carried out and optimized by using monohalogenated agentsunder phase transfer catalysis conditions. The reaction studied lead to the expected productsin good yields and the structures of various obtained compounds are easilydetermined by theusual spectroscopic methods. This kind of products can show a potent pharmacological andtherapeutic activitiesas given in the studies reported in the literature.
From Page
173
NaturalLanguageKeyword
6 , chloroquinoxaline , 2 , 3(1H , 4H)–dione , Condensation , Alkylation , o , phenylenediamine
JournalTitle
Journal Marocain De Chimie Hétérocyclique
To Page
178
JournalTitle
Journal Marocain De Chimie Hétérocyclique
Link To Document