Voltammetric investigation of sulfathiazole with Ni(II) ions

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Sulfanamide drugs were the first effective chemotherapeutic substance to be employed systematically for the prevention and cure of bacterial infections in man. The compounds containing sulphur are known as antibacterial, antifungal, anticarcinogenic and have a wide range of use. In this work the interaction of sulfathiazole(STZ), which is one of these compounds, with Ni(II) ions on the hanging mercury drop electrode has been investigated by using voltammetry. It was observed that sulfathiazole gave two cathodic peaks at -0.272 V and -1.456 V respectively, at Britton-Robinson buffer (pH 7.40) by using square wave voltammetry(SWV) and cyclic voltammetry(CV) techniques. It was determined that the reduction peak at -0.272 V belonged to Hg(I)-STZ complex and the reduction peak at -1.456 V belonged to free sulfathiazole. It was observed that as Ni(II) ions were added to the solution containing sulfathiazole the peak current of Hg(I)-STZ complex decreased, the peak current of sulfathiazole increased and a new peak reduction occured at -0.476 V. We considered that the new peak belonged to the reduction of Ni(II)-STZ complex. Consequently, it can be said that the reduction Ni(II)-STZ complex gets easy as the reduction of Hg(I)-STZ complex becomes difficult in the presence of Ni(II) ions on the hanging mercury drop electrode.

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Sulfonamide , antibiotic , voltammetry , metal complexes.

Erciyes University Journal Of The Institute Of Science an‎d Technology

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Erciyes University Journal Of The Institute Of Science an‎d Technology