مرکز منطقه ای اطلاع رساني علوم و فناوري - Neutrophil/Lymphocyte, Platelet/Lymphocyte and Platelet Large Cell Ratio Values in the Diagnosis of Colorectal Cancer Patients

Abstract :

Objective: Hemogram tests are suitable for routine use, easy to analyse and can be utilised for detecting inflammation, which plays a role in cancer etiopathogenesis. In this study, we investigated whether certain hemogram parameters that have been recently recognised as inflammation markers, such as neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV), platelet/lymphocyte ratio (PLR) and platelet large cell ratio (PLCR), may be considered as colorectal cancer (CRC) biomarkers. Materials and Methods: The data studied included results of initial hemogram tests ordered in the tertiary hospital outpatient clinic for patients diagnosed with CRC between 01.01.2019 and 31.08.2019. The control group consisted of age- and gender-matched patients visiting the same hospital outpatient clinic for general examination. The exclusion criteria were diagnoses of infection, allergies or neoplastic/leukoproliferative disorders, or the presence of hemogram results out of normal ranges. Hemogram data of both groups were statistically evaluated. Results: 492 patients diagnosed with CRC and a control group of 327 were included in the study. NLR and PLR values of CRC patients were significantly higher compared to healthy controls (P 0.001). PLCR values were significantly lower in the CRC group than those in the control group (r = –0.451; P 0.001). The cut-off values for NLR, PLR and PLCR were determined as 5.01, 251 and 43, respectively. Conclusion: The study supports the presence of inflammation in the etiopathogenesis of CRC. In colorectal cancer patients, high NLR and PLR values and low PLCR values may be an important biomarker in determining the disease.