Author/Authors
prasetya, h. lambung mangkurat university - ulin general hospital, medical faculty - department of urology, Banjarmasin, Indonesia , purnomo, b.b. university of brawijaya - saiful anwar hospital, faculty of medicine - department of urology, Malang, Indonesia , mintaroem, k. university of brawijaya - faculty of medicine, - department of pathology, Malang, Indonesia , prawiro, s.r. university of brawijaya - faculty of medicine - department of microbiology, Malang, Indonesia
Title Of Article
Sensitivity and specificity of 47 kDa polyclonal antibody for detection of bladder cancer cells in urine of hematuria patients
شماره ركورد
28675
Abstract
Objective: To investigate the performance analysis of immunocytochemistry using 47 kDa polyclonal antibody compared with cytology in urine of patients hematuria symptom. Patients and methods: Patients with a suspicion of bladder tumor based on workup of hematuria were prospectively collected. The voided urine was performed for cytology and test with 47 kDa polyclonal antibody. Results: This study involved 39 patients consisting of 35 (89.74%) male and 4 (10.25%) female patients. For male patients, they showed 6 (17.14%) of positive cytology cases and 25 (71.42%) of positive immunocytochemistry cases. For female patients, they showed 0 (0.00%) of positive cytology cases and 2 (50.00%) of positive immunocytochemistry cases. The sensitivity and specificity value for immunocytochemistry using polyclonal antibody to the 47 kDa were 100.00% (95% CI = 54.07%–100.00%) and 36.36% (95% CI = 20.40%–54.88%), respectively. The positive and negative predictive value for immunocytochemistry of polyclonal antibody to the 47 kDa were 22.22% (95% CI = 8.62%–42.26%) and 100.00% (95% CI = 73.54%–100.00%), respectively. In conclusion, urine detection with 47 kDa polyclonal antibodies has higher sensitivity value and negative predictive value (100.00%) than urine cytology. Conclusion: This technique becomes an alternative early detection of bladder cancer for high-risk populations which can be easily and specifically carried out in primary care in Indonesia.
From Page
264
NaturalLanguageKeyword
Bladder , Polyclonal antibody , Hematuria , Proteomic , Diagnostic performance
JournalTitle
African Journal of Urology
To Page
269
JournalTitle
African Journal of Urology
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