KUCUKKURT, Ismail University of Afyon Kocatepe - Faculty of Veterinary Medicine - Department of Biochemistry, Turkey , INCE, Sinan University of Afyon Kocatepe - Faculty of Veterinary Medicine - Department of Pharmacology and Toxicology, Turkey , AYTEKIN, Ismail University of Mustafa Kemal - Faculty of Veterinary Medicine - Department of Internal Medicine, Turkey , BIRDANE, Yavuz O. University of Afyon Kocatepe - Faculty of Veterinary Medicine - Department of Pharmacology and Toxicology, Turkey

The Effects of Flumethrin and Flumethrin+Vitamin C Application on Oxidative Stress Biomarkers in Chios Sheep

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Present study was undertaken to study the effects of flumethrin and flumethrin+vitamin C treatment on oxidative stress biomarkers in Chios sheep. Twenty Chios sheep were divided into 2 equal groups. A pour on flumethrin to doses of 0.2 ml/kg body weight was applied on dorsal skin and vitamin C to give an intramuscular injection amount of 0.15 ml/kg in twenty Chios sheep. Results showed that flumethrin treatment unchanged malondialdehyde levels (MDA), but with vitamin C treatment significantly decreased MDA levels in whole blood on day seven. The activities of erythrocyte catalase (CAT) and superoxide dismutase (SOD) were significantly increased in both groups whereas whole blood reduced glutathione (GSH) concentration decreased in flumethrin treatment. On the other hand, plasma nitric oxide levels (NOx) decreased in flumethrin with vitamin C application. The present study determinated that application of flumethrin with vitamin C could be no adverse effect on oxidant/antioxidant status in Chios sheep.

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Flumethrin , Lipid peroxidation , Oxidative stres , Chios sheep , Vitamin C

Kocatepe Veterinary Journal

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