Author/Authors :
Ateş, Ömer Gaziosmanpaşa Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Büdeyri, Nilay Marmara Üniversitesi - Mühendislik Fakültesi - Biyomühendislik Anabilim Dalı, Turkey , Müsellim, Benan İstanbul Üniversitesi - Cerrahpaşa Tıp Fakültesi - Göğüs Hastalıkları Anabilim Dalı, Turkey , Öngen, Gül İstanbul Üniversitesi - Cerrahpaşa Tıp Fakültesi - Göğüs Hastalıkları Anabilim Dalı, Turkey , Sarıkaya, Ayşegül Topal İstanbul Üniversitesi - Moleküler Biyoloji ve Genetik Bölümü, Turkey
Abstract :
Aim. Our aim was to investigate the association between Systemic sclerosis (SSc) and COL1A1 and COL1A2 gene polymorphisms which are thought to have a probable effect on the production of collagen. Method. We analysed COL1A1 and COL1A2 gene polymorphisms in 45 SSc women patients and 75 healthy women by using the Polymerase Chain Reaction (PCR) and Restriction Enzyme Analysis (REA). Result. It was found that the genotip and allel frequencies distribution of Sp1 and PvuII was approximately the same values in the control and patient group and also determined that there was no meaningful association between SSc and these polymorphisms. Conclusion. It was thought that Sp1 polymorphism of COL1A1 gene and PvuII polymorphism of COL1A2 gene did not play a significant role on the excessive synthesis and deposition of collagen in systemic sclerosis.
