Author/Authors :
Kılıçlı, Fatih Cumhuriyet Üniversitesi - Tıp Fakültesi - Endokrinoloji Bilim Dalı, Turkey , Dökmetaş, Hatice Sebile Cumhuriyet Üniversitesi - Tıp Fakültesi - Endokrinoloji Bilim Dalı, Turkey
Abstract :
Growth hormone secretion occurs throughout life and is known to have profound effects on anabolism, lipolysis, and carbohydrate metabolism. Until the second half of 1980’s growth hormone deficiency in adult life was not considered as a clinical problem by most endocrinologists. Growth hormone deficiency in adults is associated with reduced life expectancy, increased cardiovascular morbidity and premature atherosclerosis, changes in body composition, osteoporosis, reduced exercise tolerance and reduced quality of life. Growth hormone replacement therapy has important beneficial effects in adult hypopituitary patients with growth hormone deficiency. It is shown that growth hormone therapy has a positive influence in growth hormone deficiency patients on quality of life, bone mineral density, body composition, exercise tolerance and vascular risk factors such as blood glucose levels and lipid profile. In patients with childhood-onset growth hormone deficiency, after cessation of linear growth, growth hormone status should be reevaluated in the transition age for continued growth hormone replacement to achieve full somatic development including the maintenance of maximal bone and muscle mass.
