Author/Authors
Şener, Azize Marmara Üniversitesi - Eczacılık Fakültesi - Biyokimya Anabilim Dalı, Turkey , Çevik, Özge Marmara Üniversitesi - Eczacilik Fakültesi - Biyokimya Anabilim Dali, Turkey
Title Of Article
Association of gamma-glutamyltransferase with oxidative stress and cardiovascular diseases
شماره ركورد
33284
Abstract
The primary role of the gamma-glutamyltransferase (GGT) is to break down the extracellular glutathione (GSH) in order to provide precursor amino acids especially cysteine, required for the intracellular GSH synthesis. Thus, the enzyme shows an antioxidant effect. However, it may cause reactive oxygen species generation in the presence of transition metals during the metabolism of GGT-catalysed extracellular GSH. Recent epidemiological researches have shown that elevated serum GGT activity, within its reference level range, is a marker of cardiovascular diseases, which brought on by atherosclerosis. In this review, recent knowledge on the association between GGT and oxidative stress as well as the importance of GGT activity in the pathogenesis and clinical evaluation of Cardiovascular Diseases has been discussed.
From Page
291
NaturalLanguageKeyword
Gamma , Glutamyltransferase , glutathione , oxidative stress , cardiovascular diseases
JournalTitle
Cumhuriyet Medical Journal
To Page
301
JournalTitle
Cumhuriyet Medical Journal
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