Author/Authors
Kaya, Hakkı Sivas Numune Hospital - Cardiology Clinic, Turkey , Yücel, Hasan Cumhuriyet University - School of Medicine - Department of Cardiology, Turkey , Zorlu, Ali Cumhuriyet University - School of Medicine - Department of Cardiology, Turkey
Title Of Article
Cancer antigen 125 level is determined by tricuspid regurgitation among patients with stable systolic heart failure
شماره ركورد
33410
Abstract
Aim. Cancer antigen 125 (CA-125) is a soluble glycoprotein with high molecular weight. Recently, increased serum CA-125 levels were also documented in patients with heart failure (HF). We aimed to show what factors influence serum levels of CA-125 among patients with chronic systolic HF. Method. Patients, who had chronic systolic HF with echocardiographically determined ejection fraction (EF) 45% were enrolled into final analysis (n=56). CA-125 levels were classified into two as those with normal ( 35 U/mL) and high levels (≥35 U/mL). Results. Patients with Right ventricular (RV) dilatation had significantly higher CA-125 levels compared to those without RV dilatation. Besides, patients with RV dilatation had higher systolic pulmonary artery pressure (SPAP) levels compared to those without. Patients with high CA-125 levels had more frequent RV dilatation, higher pulmonary artery pressure, more severe tricuspid regurgitation. Tricuspid regurgitation was the only significant predictor of high CA-125 levels in patients with stable chronic systolic HF. Conclusion. It was shown in this study that tricuspid regurgitation was the only independent predictor of high CA-125 levels among patients with chronic stable systolic HF.
From Page
197
NaturalLanguageKeyword
CA , 125 , heart failure , right ventricle , tricuspid regurgitation
JournalTitle
Cumhuriyet Medical Journal
To Page
201
JournalTitle
Cumhuriyet Medical Journal
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