Author/Authors :
tay, funda eskişehir osmangazi university - faculty of sciences - department of chemistry, Turkey , duran, murat eskişehir osmangazi university - faculty of sciences - department of chemistry, Turkey , ispir, cihan eskişehir osmangazi university - faculty of sciences - department of chemistry, Turkey , demirayak, şeref medipol university - school of pharmacy - department of pharmaceutical chemistry, Turkey
Title Of Article :
DETERMINATION AND EVALUATION OF ACIDITY CONSTANTS OF SOME IMIDAZOLE AND THIAZOLE LINKED ACETAMIDE COMPOUNDS
Abstract :
In this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric method. When the molecules possessed different substituents the values of the acidity constants changed from 6.01 to 8.22 for the first protonation and from 3.07 to 4.73 for the second protonation. The first protonation under these circumstances was observed to occur on the nitrogen atom of the 2-mercaptoimidazole ring. The second protonation was observed to occur on the nitrogen atom of the thiazole ring.
NaturalLanguageKeyword :
Imidazole , Thiazole , Acetamide , Protonation paths , UV spectroscopy , pKa
JournalTitle :
Anadolu University Journal of Science and Technology. A : Applied Sciences and Engineering
