Author/Authors
ATALAY VURAL, Sevil Ankara Üniversitesi - Faculty of Veterinary Medicine - Department of Pathology, Turkey , ALCIGIR, Mehmet Eray Ankara Üniversitesi - School of Health Science - Department of Pathology, Turkey
Title Of Article
Distemper virus-induced apoptotic changes in cerebellum
شماره ركورد
34844
Abstract
In the study, it was purposed that detection of apoptotic changes with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end-labelling (TUNEL) method in the cerebellum of 10 dogs (n:3 females, n:7 males), varied 3 months to 2.5 years-old, different breed (1 Husky, 9 Mongrel) and sex (3 females, 7 males) in distemper disease. Histopathologically, acute (n:4) and chronic (n:6) nonpurulent encephalitis, moderate and/or mild demyelination, and intranuclear inclusion bodies were seen. Immunohistochemically distemper virus antigen was also detected in demyelinated white matter, astrocytes, and inclusion bodies in all dogs by using monoclonal canine distemper virus nucleoprotein sera. Morphologically multiple consendations of nuclear chromatin in astrocytes were found with Cresyl violet stain. TUNEL reaction in markedly astrocytes localized surrounding the demyelination areas, rarely inclusion bodies, gemistocytic astrocytes, Gitter cells in white matter and granular layer of cerebellum was demonstrated. The reactions in chronic inflammatory lesions were also detected in perivascular mononuclear cells.
From Page
83
NaturalLanguageKeyword
Dog , distemper virus , apoptosis , TUNEL
JournalTitle
Veterinary Journal of Ankara University
To Page
86
JournalTitle
Veterinary Journal of Ankara University
Link To Document