Author/Authors
AKKAYA, Zülfiye Yeliz Hacettepe Üniversitesi - Tıp Fakültesi - Tibbi Biyoloji Anabilim Dalı, Turkey , DİNÇER, Pervin Hacettepe Üniversitesi - Tıp Fakültesi - Tibbi Biyoloji Anabilim Dalı, Turkey
Title Of Article
The new era in therapeutic approaches: Non-coding RNAs and diseases
شماره ركورد
35217
Abstract
As a result of finding novel ribonucleic acid (RNA)’s and identifying their functions, it is now known that RNAs play a very important role for living organisms. Particularly, the ncRNAs (non-coding RNAs), which cover 62% of the genome, participate in the regulation of important processes such as cellular defense, development, differentiation, DNA replication, transcription and post-transcriptional silencing. Not surprisingly, therefore, their disruption has been linked to diseases such as cancers, neurodegenerative diseases, immunodeficiency, and cardiovascular diseases. ncRNAs have become the targets and tools of novel therapeutic approaches. By the help of identifying all functional ncRNAs that are encoded in the human genome, new therapeutic approaches may be developed and clinical trials using ncRNAbased molecules may be achieved. In this paper, we review the literature regarding the types of ncRNAs, their relation to diseases, and new diagnostic-therapeutic approaches.
From Page
5
NaturalLanguageKeyword
Non , coding RNAs , Diseases , Therapeutic applications Zülfiye Yeliz
JournalTitle
Marmara Medical Journal
To Page
10
JournalTitle
Marmara Medical Journal
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