DocumentCode
1031464
Title
Science, technology, and potential applications of therapeutic cloning
Author
Xu, Jie ; Yang, Xiangzhong
Author_Institution
Center for Regenerative Biol., Connecticut Univ., Storrs, CT, USA
Volume
23
Issue
2
fYear
2004
Firstpage
43
Lastpage
46
Abstract
In theory, although ethically debatable, females can now propagate without males and still conceive fertilized (not cloned) embryos by using oocytes and sperm derived through these mechanisms. Another alternative to the cloning technology, which attempts to avoid the current debate on ethics and policy, is the artificial haploidization of somatic cells As reproductive gametes or sex cells (sperm and eggs) are haploid (have half the number of chromosomes), but somatic cells are diploid (chromosomes are doubled), effort has been made to create artificial gametes via reducing the diploid somatic cells into haploid gamete-like cells. Theoretically, these "haploid" cells can subsequently be combined in a fashion similar to fertilization and develop into an embryo. Obviously, this approach may potentially create more ethical debate than therapeutic cloning.
Keywords
cellular biophysics; genetic engineering; adult tissues; artificial gametes; bone marrow; brain; cloning technology; eggs; ethical problems; haploidization; muscle; reproductive gametes; sex cells; skin; somatic cells; sperm; stem cells; therapeutic cloning; Animals; Cells (biology); Cloning; Embryo; Immune system; In vitro; Medical treatment; Pregnancy; Production; Stem cells; Animals; Biotechnology; Cloning, Organism; Embryo Research; Genetic Engineering; Humans; Reproductive Techniques, Assisted; Science; Stem Cell Transplantation;
fLanguage
English
Journal_Title
Engineering in Medicine and Biology Magazine, IEEE
Publisher
ieee
ISSN
0739-5175
Type
jour
DOI
10.1109/MEMB.2004.1310973
Filename
1310973
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