• DocumentCode
    1031464
  • Title

    Science, technology, and potential applications of therapeutic cloning

  • Author

    Xu, Jie ; Yang, Xiangzhong

  • Author_Institution
    Center for Regenerative Biol., Connecticut Univ., Storrs, CT, USA
  • Volume
    23
  • Issue
    2
  • fYear
    2004
  • Firstpage
    43
  • Lastpage
    46
  • Abstract
    In theory, although ethically debatable, females can now propagate without males and still conceive fertilized (not cloned) embryos by using oocytes and sperm derived through these mechanisms. Another alternative to the cloning technology, which attempts to avoid the current debate on ethics and policy, is the artificial haploidization of somatic cells As reproductive gametes or sex cells (sperm and eggs) are haploid (have half the number of chromosomes), but somatic cells are diploid (chromosomes are doubled), effort has been made to create artificial gametes via reducing the diploid somatic cells into haploid gamete-like cells. Theoretically, these "haploid" cells can subsequently be combined in a fashion similar to fertilization and develop into an embryo. Obviously, this approach may potentially create more ethical debate than therapeutic cloning.
  • Keywords
    cellular biophysics; genetic engineering; adult tissues; artificial gametes; bone marrow; brain; cloning technology; eggs; ethical problems; haploidization; muscle; reproductive gametes; sex cells; skin; somatic cells; sperm; stem cells; therapeutic cloning; Animals; Cells (biology); Cloning; Embryo; Immune system; In vitro; Medical treatment; Pregnancy; Production; Stem cells; Animals; Biotechnology; Cloning, Organism; Embryo Research; Genetic Engineering; Humans; Reproductive Techniques, Assisted; Science; Stem Cell Transplantation;
  • fLanguage
    English
  • Journal_Title
    Engineering in Medicine and Biology Magazine, IEEE
  • Publisher
    ieee
  • ISSN
    0739-5175
  • Type

    jour

  • DOI
    10.1109/MEMB.2004.1310973
  • Filename
    1310973