DocumentCode :
1063947
Title :
Biologic computational building blocks
Author :
Capstick, Myles H. ; Marnane, W. P Liam ; Pethig, Ronald
Author_Institution :
Inst. of Molecular & Biomolecular Electron., Wales Univ., Bangor, UK
Volume :
25
Issue :
11
fYear :
1992
Firstpage :
22
Lastpage :
29
Abstract :
Methods to represent the biological activity of oxidoreductase enzymes using logic state diagrams and to simulate the enzymes´ functionings using synchronous sequential digital circuits are presented. The steps of this transform from biologics to logic involve the enzymes ´electron kinetic behavior, which reveals the basic reaction pathways of the enzyme building blocks. Because these pathways are well defined, with each enzyme going through several different conformations, each conformation can be defined in terms of a logic state. The definitions can be used to describe a state machine for the enzyme building block.<>
Keywords :
automata theory; biomolecular electronics; proteins; sequential circuits; biological activity; electron kinetic behavior; enzyme building block; enzymes´ functionings; logic state diagrams; oxidoreductase enzymes; state machine; synchronous sequential digital circuits; Biochemistry; Biological system modeling; Biology computing; Circuit simulation; Computational modeling; Digital circuits; Electrons; Kinetic theory; Logic; Sequential circuits;
fLanguage :
English
Journal_Title :
Computer
Publisher :
ieee
ISSN :
0018-9162
Type :
jour
DOI :
10.1109/2.166401
Filename :
166401
Link To Document :
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