Nanoparticle delivery enhancement with acoustically activated microbubbles

Author

Mullin, L.B. ; Phillips, L.C. ; Dayton, P.A.

Author_Institution

Joint Dept. of Biomed. Eng., Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Volume

60

Issue

1

fYear

2013

fDate

Jan-13

Abstract

The application of microbubbles and ultrasound to deliver nanoparticle carriers for drug and gene delivery is an area that has expanded greatly in recent years. Under ultrasound exposure, microbubbles can enhance nanoparticle delivery by increasing cellular and vascular permeability. In this review, the underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed. Additionally, types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits of a microbubble- based approach to nanoparticle delivery, are reviewed.

Keywords

biomedical ultrasonics; bubbles; cellular biophysics; drug delivery systems; gene therapy; nanomedicine; nanoparticles; permeability; acoustically activated microbubbles; cellular permeability; drug delivery; gene delivery; microbubble-based approach; nanoparticle carriers; nanoparticle delivery enhancement; ultrasound application; vascular permeability; Acoustics; Drugs; Nanoparticles; Permeability; Plastics; Tumors; Ultrasonic imaging; Animals; Gene Transfer Techniques; Mice; Microbubbles; Nanoparticles; Ultrasonics;

fLanguage

English

Journal_Title

Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on

Publisher

ieee

ISSN

0885-3010

Type

jour

DOI

10.1109/TUFFC.2013.2538

Filename

6396487