Development of a 3D gradient-based method for volume quantitation in SPECT

Author

Long, David T. ; King, Michael A. ; Gennert, Michael A.

Author_Institution

Dept. of Nucl. Med., Massachusetts Univ. Med. Center, Worcester, MA, USA

Volume

38

Issue

2

fYear

1991

fDate

4/1/1991 12:00:00 AM

Firstpage

748

Lastpage

754

Abstract

A three-dimensional (3-D) method for quantifying organ and lesion volume in SPECT (single photon emission computed tomography) is described. A 3-D edge-detection technique based on a 3-D gradient operator is used to define the boundary of a radionuclide distribution in typical low-contrast, high-noise SPECT images. The method combines pre- and post-reconstruction filtering of the SPECT images with a 3-D adaptation of interpolative background subtraction to provide adequate noise reduction for reliable boundary definition. Simulation studies have shown that the method provides a direct measurement of relatively small volumes in SPECT images with good reproducibility and minimal operator bias. The method is applicable to quantifying the volume of hot and cold lesions

Keywords

computerised tomography; picture processing; radioisotope scanning and imaging; volume measurement; 3D edge-detection technique; 3D gradient-based method; SPECT; cold lesions; hot lesions; image filtering; interpolative background subtraction; lesion volume; medical diagnostic imaging; nuclear medicine; operator bias; organ volume; radionuclide distribution; reliable boundary definition; single photon emission computed tomography; volume quantitation; Adaptive filters; Biomedical imaging; Computer science; Filtering; Image edge detection; Image resolution; Image segmentation; Lesions; Noise reduction; Nuclear medicine;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.289384

Filename

289384