DocumentCode :
1112090
Title :
Detection and Visualization of Surface-Pockets to Enable Phenotyping Studies
Author :
Mosaliganti, Kishore ; Janoos, Firdaus ; Sharp, Richard ; Ridgway, Randall ; Machiraju, Raghu ; Huang, Kun ; Wenzel, Pamela ; DeBruin, Alain ; Leone, Gustavo ; Saltz, Joel
Author_Institution :
Ohio State Univ., Columbus
Volume :
26
Issue :
9
fYear :
2007
Firstpage :
1283
Lastpage :
1290
Abstract :
In this paper, we propose a technique for detecting pockets on a surface-of-interest. A sequence of propagating fronts converging to the target surface is used as the basis for inspection. We compute a correspondence function between the initial and the target surface. This leads to a natural definition of the local feature size measured as the evolution distance between mapped points. Surface pockets are then extracted as salient clusters embedded in the feature space. The level-set initialization also determines the scale-space of the extracted pockets. Results are presented on a case-study in which the focus is to chronicle the phenotyping differences in genetically modified mouse placenta. Our results are validated based on manually verified ground-truth.
Keywords :
medical image processing; converging propagating front sequence; correspondence function; genetically modified mouse placenta; ground truth; local feature size definition; phenotyping studies; surface pocket detection; surface pocket visualization; Biomedical engineering; Biomedical imaging; Computer science; Drugs; Mice; Proteins; Surface fitting; Surface morphology; Surface reconstruction; Visualization; Computational phenotyping; level-sets; surface-pockets; Algorithms; Animals; Artificial Intelligence; Female; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Mice; Pattern Recognition, Automated; Phenotype; Placenta; Placenta Diseases; Pregnancy; Pregnancy, Animal; Reproducibility of Results; Retinoblastoma Protein; Sensitivity and Specificity; Surface Properties; User-Computer Interface;
fLanguage :
English
Journal_Title :
Medical Imaging, IEEE Transactions on
Publisher :
ieee
ISSN :
0278-0062
Type :
jour
DOI :
10.1109/TMI.2007.903570
Filename :
4298154
Link To Document :
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