Modular design for in vivo optical imaging and ultrasound treatment in the murine brain

Author

Raymond, Scott B. ; Skoch, Jesse ; Bacskai, Brian J. ; Hynynen, Kullervo

Author_Institution

Div. of Health Sci. & Tech., MIT, Boston, MA

Volume

54

Issue

2

fYear

2007

fDate

2/1/2007 12:00:00 AM

Firstpage

431

Lastpage

434

Abstract

Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption

Keywords

biomedical optical imaging; biomedical ultrasonics; blood; brain; patient treatment; blood-brain barrier disruption; commercial multiphoton microscope; in vivo optical imaging; modular design; mouse ventral surface; murine brain; sonication; ultrasound exposure; ultrasound treatment; Acoustic transducers; Focusing; In vivo; Mice; Microscopy; Optical design; Optical imaging; Skull; Ultrasonic imaging; Ultrasonic transducers; Animals; Blood-Brain Barrier; Brain; Equipment Design; Equipment Failure Analysis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Sonication; Systems Integration; Ultrasonic Therapy;

fLanguage

English

Journal_Title

Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on

Publisher

ieee

ISSN

0885-3010

Type

jour

DOI

10.1109/TUFFC.2007.257

Filename

4107702