DocumentCode :
1205398
Title :
A three-dimensional microelectrode array for chronic neural recording
Author :
Hoogerwerf, Arnold C. ; Wise, Kensall D.
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Michigan Univ., Ann Arbor, MI, USA
Volume :
41
Issue :
12
fYear :
1994
Firstpage :
1136
Lastpage :
1146
Abstract :
Describes a 3-D microelectrode array for the chronic recording of single-unit activity in the central nervous system. The array is formed by a microassembly of planar silicon multishank microprobes, which are precisely positioned in a micromachined platform that resides on the surface of the cortex. Interconnects between the probes and the platform are formed using electroplated nickel lead transfers, implemented using automated computer control. All dimensions are controlled to ±1 μm and shank/probe separations as small as 100 μm are possible. Four-probe 16-shank prototype arrays have been tested chronically in guinea pig cortex. After three months in vivo, no significant tissue reaction has been observed surrounding these structures when they remain free to move with the brain, with normal appearing tissue between shanks spaced at 150 μm to 200 μm intervals. The array structure is compatible with the use of signal processing circuitry both on the probes and on the platform. A platform-based signal processing system has been designed to interface with several active probes, providing direct analog access to the recording sites, performing on-chip analog-to-digital conversion of neural activity, and providing simple binary-output recognition of single-unit spike events using a user-input threshold voltage.
Keywords :
biological techniques; microelectrodes; neurophysiology; 100 to 200 mum; 3 month; 3D microelectrode array; automated computer control; brain; chronic neural recording; electroplated nickel lead transfers; guinea pig cortex; neuroscience technique; planar silicon multishank microprobes microassembly; platform-based signal processing system; simple binary-output recognition; single-unit spike events; tissue reaction; user-input threshold voltage; Array signal processing; Automatic control; Central nervous system; Integrated circuit interconnections; Microassembly; Microelectrodes; Nickel; Probes; Prototypes; Silicon; Animals; Biocompatible Materials; Cerebral Cortex; Electric Impedance; Electrodes, Implanted; Electroencephalography; Equipment Design; Guinea Pigs; Microelectrodes; Microscopy, Electron, Scanning; Signal Processing, Computer-Assisted;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/10.335862
Filename :
335862
Link To Document :
بازگشت