Tissue perfusion in Fluid therapy

Author

Siam, Jamal ; Barnea, O.

Author_Institution

Dept. of Biomed. Eng., Tel Aviv Univ., Tel Aviv, Israel

fYear

2014

fDate

17-20 Feb. 2014

Firstpage

196

Lastpage

199

Abstract

Fluid resuscitation affects blood flow and oxygen concentration. Administered fluid increases blood flow and oxygen delivery rate but also decreases blood oxygen concentration. This study aims at analyzing these two effects on oxygen supply to tissue to determine an optimal fluid regimen. For this purpose a hemodynamic model of the cardiovascular system and a model of oxygen transfer to tissue were developed and combined. Simulation results showed that indeed fluid administration increases oxygen delivery by the blood stream. However, oxygen transfer to tissue deteriorates during the course of the fluid therapy due to the high sensitivity of oxygen diffusion to oxygen partial pressure in the blood.

Keywords

biodiffusion; biological tissues; haemodynamics; patient treatment; blood flow; blood oxygen concentration; blood stream; cardiovascular system; fluid resuscitation; fluid therapy; hemodynamic model; optimal fluid regimen; oxygen concentration; oxygen delivery; oxygen delivery rate; oxygen partial pressure; oxygen transfer model; tissue perfusion; Biological system modeling; Blood; Blood flow; Fluids; Hemorrhaging; Mathematical model; Medical treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering (MECBME), 2014 Middle East Conference on

Conference_Location

Doha

Type

conf

DOI

10.1109/MECBME.2014.6783239

Filename

6783239