DocumentCode :
1231456
Title :
A Polymer Microfluidic Chip With Interdigitated Electrodes Arrays for Simultaneous Dielectrophoretic Manipulation and Impedimetric Detection of Microparticles
Author :
Zou, Zhiwei ; Lee, Soohyun ; Ahn, Chong H.
Author_Institution :
Dept. of Electr. & Comput. Eng., Cincinnati Univ., Cincinnati, OH
Volume :
8
Issue :
5
fYear :
2008
fDate :
5/1/2008 12:00:00 AM
Firstpage :
527
Lastpage :
535
Abstract :
This paper presents the design, fabrication, and characterization of a polymer microfluidic biochip with integrated interdigitated electrodes arrays (IDAs) used to simultaneously separate, manipulate, and detect microparticles using dielectrophoresis (DEP) and electrochemical impedance spectroscopy (EIS) methods. The DEP response of silica microspheres has been characterized, and microspheres of different sizes (1.8 and 3.5 in diameter) have been DEP flow separated and individually trapped in different microchambers by IDAs in a single run. Simultaneously, the impedance change caused by microspheres captured on IDAs has been analyzed for quantification. High-throughput polymer microfabrication techniques such as micro injection molding were used in this work, so that the polymer microfluidic chip can be produced in a low-cost, disposable platform. This low-cost microfluidic chip provides a generic platform for developing multifunctional lab-on-a-chip devices that require the ability to handle and sense microparticles.
Keywords :
biomedical electronics; electrochemical impedance spectroscopy; electrophoresis; lab-on-a-chip; microfluidics; EIS methods; dielectrophoretic manipulation; electrochemical impedance spectroscopy; integrated interdigitated electrodes arrays; microchambers; microinjection molding; microparticle impedimetric detection; multifunctional lab-on-a-chip devices; polymer microfabrication techniques; polymer microfluidic biochip; Dielectrophoresis; Electrochemical impedance spectroscopy; Electrodes; Lab-on-a-chip; Microfluidics; Microorganisms; Nanobioscience; Nanoparticles; Polymers; Silicon compounds; Dielectrophoresis (DEP); electrochemical impedance spectroscopy (EIS); interdigitated electrodes arrays (IDAs); microparticles;
fLanguage :
English
Journal_Title :
Sensors Journal, IEEE
Publisher :
ieee
ISSN :
1530-437X
Type :
jour
DOI :
10.1109/JSEN.2008.918907
Filename :
4529161
Link To Document :
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