Dielectrophoretic Response of DNA Shows Different Conduction Mechanisms for Poly(dG)-Poly(dC) and Poly(dA)-Poly(dT) in Solution

Author

Mohamad, Ahmad Sabry ; Jeynes, J.C.G. ; Hughes, M.P.

Author_Institution

Dept. of Mech. Eng. Sci., Univ. of Surrey, Guildford, UK

Volume

13

Issue

1

fYear

2014

fDate

Mar-14

Firstpage

51

Lastpage

54

Abstract

Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.

Keywords

DNA; biochemistry; bioelectric phenomena; electrophoresis; ionic conductivity; molecular biophysics; AT DNA conduction; GC DNA; conduction mechanisms; counterion cloud; dielectrophoretic response; electrical properties; ionic conduction mechanisms; poly(da)-poly(dt) DNA; poly(dg)-poly(dc) DNA; Conductivity; DNA; Dielectrophoresis; Electric potential; Electrodes; Force; Time-frequency analysis; Bioelectric phenomena; DNA; dielectrophoresis; electrokinetic; molecular biophysics;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2014.2299215

Filename

6750134