Title :
On-chip patch-clamp sensor for solid-state nanopore applications
Author :
Kim, Jung-Ho ; Pedrotti, K.D. ; Dunbar, W.B.
Author_Institution :
Dept. of Electr. Eng., Univ. of California at Santa Cruz, Santa Cruz, CA, USA
Abstract :
An integrated low-noise patch-clamp sensor is implemented for single-molecule DNA analysis using a solid-state nanopore. By adopting an instrumentation amplifier and a compensation switch for the headstage, the input-offset voltage and the deleterious effects of input parasitic capacitances are minimised. This high-sensitivity sensor amplifier was fabricated in a 0.35 μm CMOS process and tested with the solid-state nanopore also developed.
Keywords :
CMOS integrated circuits; DNA; bioelectric phenomena; capacitance; instrumentation amplifiers; lab-on-a-chip; CMOS process; compensation switch; input-offset voltage; instrumentation amplifier; on-chip patch-clamp sensor; parasitic capacitance; single-molecule DNA analysis; size 0.35 mum; solid-state nanopore application;
Journal_Title :
Electronics Letters
DOI :
10.1049/el.2011.1515
