DocumentCode :
129626
Title :
Neointima reduction with IVUS and rapamycin microbubbles: In Vivo swine model results
Author :
Kilroy, Joseph P. ; Dhanaliwala, Ali H. ; Wamhoff, Brian R. ; Klibanov, Alexander L. ; Bowles, Douglas K. ; Hossack, John A.
Author_Institution :
Biomed. Eng., Univ. of Virginia, Charlottesville, VA, USA
fYear :
2014
fDate :
3-6 Sept. 2014
Firstpage :
13
Lastpage :
16
Abstract :
An intravascular ultrasound (IVUS) catheter, optimized for microbubble-enhanced drug delivery, was used to reduce neointima formation in a swine model of balloon injury. In order to minimize neointima formation following balloon injury, rapamycin-loaded microbubbles were infused into the region of injury. During microbubble infusion, arteries were treated with, or without, IVUS catheter insonation. Twenty eight days after treatment, injured arteries were excised, sectioned, and imaged. A reduction in neointima formation of 65% was measured in arteries treated with IVUS and rapamycin-loaded microbubbles as compared to arteries treated with rapamycin-loaded microbubbles alone (no ultrasound). These results indicate that IVUS, paired with drug-loaded microbubbles, may be a viable approach for achieving localized delivery of intravascular antiproliferative therapies.
Keywords :
biomedical ultrasonics; blood vessels; bubbles; catheters; drug delivery systems; injuries; ultrasonic imaging; ultrasonic therapy; IVUS catheter insonation; arteries; balloon injury; drug-loaded microbubbles; in vivo swine model; intravascular antiproliferative therapy; intravascular ultrasound catheter; microbubble infusion; microbubble-enhanced drug delivery; neointima reduction; rapamycin microbubbles; Arteries; Catheters; Drug delivery; Drugs; Injuries; Transducers; Ultrasonic imaging; Ultrasound; intravascular ultrasound; microbubbles; therapeutics;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2014 IEEE International
Conference_Location :
Chicago, IL
Type :
conf
DOI :
10.1109/ULTSYM.2014.0004
Filename :
6932083
Link To Document :
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