DocumentCode :
1307499
Title :
A Preliminary Model of Gastrointestinal Electromechanical Coupling
Author :
Du, Peng ; Poh, Yong Cheng ; Lim, Jee Lean ; Gajendiran, Viveka ; OrGrady, G. ; Buist, Martin L. ; Pullan, Andrew J. ; Cheng, Leo K.
Author_Institution :
Auckland Bioeng. Inst., Univ. of Auckland, Auckland, New Zealand
Volume :
58
Issue :
12
fYear :
2011
Firstpage :
3491
Lastpage :
3495
Abstract :
Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including electrical slow wave activity, the enteric nervous system (ENS), and other factors. Slow waves generated in interstitial cells of Cajal (ICC) depolarize smooth muscle cells (SMC), generating basic GI contractions. This unique electrical coupling presents an added layer of complexity to GI electromechanical models, and a current barrier to further progress is the lack of a framework for ICC-SMC-contraction coupling. In this study, an initial framework for the electromechanical coupling was developed in a 2-D model. At each solution step, the slow wave propagation was solved first and in the SMC model was related to a -tension-extension relationship to simulate active contraction. With identification of more GI-specific constitutive laws and material parameters, the ICC-SMC-contraction approach may underpin future GI electromechanical models of health and disease states.
Keywords :
bioelectric phenomena; biomechanics; cellular biophysics; electromechanical effects; muscle; neurophysiology; physiological models; 2D model; Ca2+-tension-extension relationship; GI electromechanical model; Gl-specific constitutive law; ICC-SMC-contraction approach; SMC model; active contraction; current barrier; disease states; electrical coupling; electrical slow wave activity; enteric nervous system; gastrointestinal electromechanical coupling; gastrointestinal motility; interstitial cells; material parameters; slow wave propagation; smooth muscle cells; Adaptation models; Couplings; Force; Gastrointestinal tract; IP networks; Mathematical model; Muscles; Bidomain; interstitial cells of Cajal (ICC); motility; slow waves; smooth muscle cells (SMC); Calcium; Electrophysiological Phenomena; Gastrointestinal Motility; Gastrointestinal Tract; Humans; Interstitial Cells of Cajal; Mechanotransduction, Cellular; Models, Biological; Muscle, Smooth;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2011.2166155
Filename :
5999709
Link To Document :
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