DocumentCode :
1311423
Title :
On the Modeling of New Tunnel Junction Magnetoresistive Biosensors
Author :
De Almeida, Teresa Mendes ; Piedade, Moisé S S ; Sousa, Leonel Augusto ; Germano, José ; Lopes, Paulo A C ; Cardoso, Filipe Arroyo ; Freitas, Paulo Peixeiro
Author_Institution :
Inst. de Eng. de Sist. e Comput.-R&D (INESC-ID), Lisbon, Portugal
Volume :
59
Issue :
1
fYear :
2010
Firstpage :
92
Lastpage :
100
Abstract :
A fully integrated biochip based on a 16 ?? 16 scalable matrix structure of aluminum oxide magnetic tunnel junctions (MTJs) and thin-film diodes (TFDs of hydrogenated amorphous silicon) was fabricated and included as the biosensor of a portable handheld microsystem developed for biomolecular recognition detection using magnetic labels [deoxyribonucleic acid (DNA) hybridization, antibody antigen interaction, etc.]. The system uses magnetic field arraying of magnetically tagged biomolecules and can potentially be used to detect single or few biomolecules. Each biosensor matrix node is the series between a TFD (p-i-n or Schottky-barrier type) and an MTJ. In this paper, this matrix basic cell biosensor element is completely characterized and modeled. Experimental measured data are provided and compared with the proposed theoretical models results. It is shown that the diode may be used both as the matrix switching device and as an in-site temperature sensor and that the MTJ may act as the magnetoresistive sensor for detecting the fringe field of immobilized magnetic markers. Therefore, the fabricated fully integrated biochip included in the developed handheld microsystem may be used for biomolecular recognition.
Keywords :
DNA; biosensors; magnetoresistive devices; molecular biophysics; portable instruments; DNA hybridization; antibody antigen interaction; biomolecular recognition; deoxyribonucleic acid; magnetic field arraying; magnetoresistive biosensors; portable handheld microsystem; thin film diodes; tunnel junction; Biomedical transducers; Schottky diodes; magnetoresistive devices; p-i-n diodes; system modeling;
fLanguage :
English
Journal_Title :
Instrumentation and Measurement, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9456
Type :
jour
DOI :
10.1109/TIM.2009.2022100
Filename :
5325788
Link To Document :
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